He married Nam Tran Chuon, a beauty queen from Hue, and they had three children. He exemplified this personal and family commitment by going from a small law practice in the small Cochin-Chinese (South Vietnamese) town of Bac Lieu in the 1920s to becoming Vietnam’s first foreign secretary under the Japanese occupation during World War II.

His daughter Le Xuan known as "Madame Nhu" married Ngo Dinh Nhu, the brother of South Vietnam's first President Ngo Dinh Diem.

Tran Van Chuong was appointed as Ambassador to Washington, by his son-inlaw President Ngo Dinh Diem.

On November 1, 1963 her son-inlaw Ngo Dinh Nhu and his brother President Ngo Dinh Diem were assassinated in a coup d'etat led by General Duong Van Minh with the understanding that the United States would not intervene.

His daughter Madame Nhu was in Beverly Hills, California at the time since October, with her daughter, Le Thuy, for a trip to the United States and Italy, where she intended to expose a scheming President John F. Kennedy and the CIA to the American public.

He and wife remained in the United States and remained in Washington D.C..

On November 2, 1986, they were allegedly strangled by their son Tran Van Khiem at their home, which their daughter Madame Nhu charged the United States for hounding her family with the arrest of her younger brother.

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