Events

• The first official translation of the entire Bible in Swedish
• February 12 - Pedro de Valdivia founds Santiago de Chile.
• May 8 - Hernando de Soto reaches the Mississippi River naming it Rio de Espiritu Santo.
• May 23 - Jacques Cartier departs Saint-Malo France on his third voyage.
• August 29 - The Janissaries of Suleiman the Magnificent take Buda by ruse, hiding themselves as tourists.
• Muslims seal off The Golden Gate in Jerusalem.
• Irish Parliament declares Ireland to be a kingdom

Births

• March 21 - Francesco I de' Medici, Grand Duke of Tuscany (died 1587)
• April 8 - Michele Mercati, physician who was superintendent of the Vatican Botanical Garden (died 1593)
• Pierre Charron, French philosopher (died 1603)
• Walter Devereux, 1st Earl of Essex, English nobleman (died 1576)
• El Greco, Spanish artist (died 1614)
• Hatano Hideharu, Japanese samurai (died 1579)
• Abe Masakatsu, important member of the Abe clan of Mikawa
• Mizuno Tadashige, Japanese nobleman (died 1600)
• Guðbrandur Þorláksson, mathematician

Deaths

• May 27 - Margaret Pole, 8th Countess of Salisbury, daughter of George, Duke of Clarence (executed) (born 1473)
• June 26 - Francisco Pizarro, Spanish conquistador (born 1475)
• July 4 - Pedro de Alvarado, Spanish conquistador (born 1495)
• August 1 - Simon Grynaeus, German scholar and theologian (born 1493)
• September 24 - Paracelsus, famous alchemist
• November 24 - Margaret Tudor, queen of James IV of Scotland (born 1489)
• Francisco Alvarez, Portuguese missionary and explorer (born 1465)
• Wolfgang Fabricius Capito, German reformer
• Jean Clouet, French miniature painter
• Thomas Culpeper, young courtier in Henry VIII's time
• Giovanni Guidiccioni, Italian poet (born 1480)
• Andreas Karlstadt, Christian theologian and reformer
• Gendun Gyatso, 2nd Dalai Lama
• Jerzy Radziwill, Polish nobleman (born 1480)
• Amago Tsunehisa, Japanese warlord
• Juan de Valdés, Spanish religious writer (born 1500)

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